Sorption of nonsteroidal anti-inflammatory drugs from aqueous media by aluminosilicate ceramic microspheres

Authors

  • Alexey A. Kushnir Voronezh State University of Engineering Technologies
  • Alexander S. Gubin Voronezh State University of Engineering Technologies
  • Kseniya S. Sypko North Caucasus Federal University
  • Alexey A. Shigida Voronezh State University of Engineering Technologies
  • Pavel T. Sukhanov Voronezh State University of Engineering Technologies

DOI:

https://doi.org/10.17308/sorpchrom.2026.26/14185

Keywords:

sorption, aluminosilicate ceramic microspheres, cenospheres, nonsteroidal anti-inflammatory drugs, ibu-profen, nimesulide, diclofenac

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs), along with antifungal, antiepileptic drugs, sex hormones, and beta-blockers, are the most common pharmaceutical preparations that often enter various water bodies through industrial wastewater due to irrational use and improper disposal. The most common NSAIDs used by consumers are ibuprofen (IB), nimesulide (NM), diclofenac (DC), ketoprofen (KT), and piroxicam (PC). This work aimed to study the sorption of NSAIDs from aqueous media using aluminosilicate microspheres, including establishing the sorption conditions (pH, sorbent mass, time to reach sorption equilibrium).

Aluminosilicate ceramic microspheres (cenospheres) from INOTEK Holding (Russia) were selected as the sorbent.

The efficiency of NSAID sorption, which differs in structure and pKa, depends on the pH of the solution. The extraction degree of DC, IB, and KT decreases with increasing pH, reaching a maximum at pH 1-2, i.e., at values above pKa. pH has a more complex effect on PC sorption: at pH 1-2 it is present in the solution in cationic form, then at pH 3-6 its content decreases, and a mixture of neutral, cationic, and anionic forms is present in the solution.

An important parameter affecting sorption efficiency is the ratio of the sorbate solution volume to the sorbent mass. During sorption from a solution volume of 10 cm³, the extraction degree increases in the sorbent mass range from 5 to 15 mg by 40-94%, while in the range of 20-40 mg it increases by only 1-2%.

With increasing phase contact time from 0 to 45 min, sorption efficiency smoothly increases from 15-20%
(10 min) to 40-69% (45 min). The curve reaches a plateau at 45-90 min. With further increase in phase contact time (120 min), the NSAID extraction degree increases by 1-3%. The pseudo-second-order model is applicable for describing the sorption kinetics (R² = 0.951-0.981).

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Author Biographies

  • Alexey A. Kushnir, Voronezh State University of Engineering Technologies

    Ph.D., Associate Professor of the Department of Industrial Ecology and Technosphere Safety, Voronezh State University of Engineering Technologies, Voronezh, Russian Federation

  • Alexander S. Gubin, Voronezh State University of Engineering Technologies

    Ph.D., doctor of science (chemistry), Department of Industrial Ecology and Technosphere Safety, Voronezh State University of Engineering Technologies, Voronezh, Russian Federation

  • Kseniya S. Sypko, North Caucasus Federal University

    Ph.D., Acting Head of the Department of Chemistry and Chemical Technology Federal State Autonomous Educational  Institution  for  Higher  Education "North-Caucasus Federal University", Russian Federation

  • Alexey A. Shigida, Voronezh State University of Engineering Technologies

    student, Department of Physical and Analytical Chemistry, Voronezh State University of Engineering Technologies, Voronezh, Russian Federation

  • Pavel T. Sukhanov, Voronezh State University of Engineering Technologies

    professor, doctor of science (chemistry), Department of Physical and Analytical Chemistry, Voronezh State University of Engineering Technologies, Voronezh, Russian Federation

References

1. Moreno Ríos A.L., Gutierrez-Suarez K., Carmona Z., Ramos C.G., Silva Oliveira L.F. Chemosphere. 2022; 291(Pt 1): 132822. https://doi.org/10.1016/j.chemosphere.2021.132822

2. Vaudin P., Augé C., Just N., Mhaouty-Kodja S., Mortaud S., Pillon D. Environ. Res. 2022; 205: 112495. https://doi.org/10.1016/j.envres.2021.112495

3. Marmon P., Owen S.F., Margiotta-Casaluci L. Environ. Int. 2021; 146: 106222. https://doi.org/10.1016/j.envint.2020.106222

4. Rozaini M.N.H., Semail N.-F., Zango Z.U., Lim J.W., Yahaya N., Setiabudi H.D., Tong W.-Y., Shamsuddin R., Chan Y.J., Khoo K.S., Suliman M., Kiatkittipong W. J. Taiwan Inst. Chem. Eng. 2025; 166: 105020. https://doi.org/10.1016/j.jtice.2023.105020

5. Parolini M. Sci. Total Environ. 2020; 740: 140043. https://doi.org/10.1016/j.scitotenv.2020.140043

6. Kushnir A.A., Sypko K.S., Gubin A.S., Sheremet E.O., Sukhanov P.T. Sorbtsionnye I Khromatograficheskie Protsessy. 2021; 21(2): 196-215. (In Russ.) https://doi.org/10.17308/sorpchrom.2021.21/3354

7. Cobian-Solorio G.A., Aguayo-Villarreal I.A., Rojas-Mayorga C.K., Muñiz-Valencia R., Emparan-Legaspi M.J., Davila Guzman N.E. J. Mol. Struct. 2025; 1321: 139698. https://doi.org/10.1016/j.molstruc.2024.139698

8. Lin Z., Jin Y., Xiao Z., Li Y., Lin Y., Chen Z., Zhuang X., Mo P., Liu Y., Chen P., Lv W., Liu G. Sep. Purif. Technol. 2024; 339: 126628. https://doi.org/10.1016/j.seppur.2024.126628

9. Costa R.L.T., do Nascimento R.A., de Araújo R.C.S., Vieira M.G.A., da Silva M.G.C., de Carvalho S.M.L., de Faria L.J.G. J. Mol. Liq. 2021; 343: 116980. https://doi.org/10.1016/j.molliq.2021.116980

10. Jana P., Bruzzoniti M.C., Appendini M., Rivoira L., Del Bubba M., Rossini D., Ciofi L., Sorarù G.D. Ceram. Int. 2016; 42(16): 18937-18943. https://doi.org/10.1016/j.ceramint.2016.09.045

11. de Souza R.M., Quesada H.B., Cusioli L.F., Fagundes-Klen M.R., Bergamasco R. Ind. Crops Prod. 2021; 161: 113200. https://doi.org/10.1016/j.indcrop.2020.113200

12. Abbas G., Javed I., Iqbal M., Haider R., Hussain F., Qureshi N. Desalination Water Treat. 2017; 95: 274-285. https://doi.org/10.5004/dwt.2017.21465

13. Viscusi G., Mottola S., Boumezough Y., Arris S., De Marco I., Gorrasi G. Chemo-sphere. 2025; 376: 144293. https://doi.org/10.1016/j.chemosphere.2025.144293

14. Sellaoui L., Mechi N., Lima É.C., Dotto G.L., Ben Lamine A. J. Phys. Chem. Solids. 2017; 109: 117-123. https://doi.org/10.1016/j.jpcs.2017.05.019

15. https://inoteck.net/keramicheskaya_mikrosfer

16. Xu X., Li Q., Cui H., Pang J., Sun L., An H., Zhai J. Desalination. 2011; 272(1-3): 233-239. https://doi.org/10.1016/j.desal.2011.01.028

17. Olabemiwo F., Tawabini B., Patel F., Oyehan T., Khaled M., Laoui T. Desalination Water Treat. 2018; 127: 140-150. https://doi.org/10.5004/dwt.2018.22859

18. Kunecki P., Wdowin M., Hanc E. J. Clean. Prod. 2023; 391: 136181. https://doi.org/10.1016/j.jclepro.2023.136181

19. Sun J., Li R., Wang X., Zhao C., Song Q., Liu F., Wang Z., Liu C., Zhang X. Chemo-sphere. 2023; 330: 138619. https://doi.org/10.1016/j.chemosphere.2023.138619

20. Lin L., Huang M., Long L., Chen D. Journal of Alloys and Compounds. 2014; 615: 929-932. https://doi.org/10.1016/j.jallcom.2014.06.088

21. Eltaweil A.S., Elgarhy G.S., El-Subruiti G.M., Omer A.M. Int. J. Biol. Macromol. 2020; 154: 307-318. https://doi.org/10.1016/j.ijbiomac.2020.03.122.

22. Khadir A., Motamedi M., Negarestani M., Sillanpää M., Sasani M. Int. J. Biol. Mac-romol. 2020; 162: 663-677. https://doi.org/10.1016/j.ijbiomac.2020.06.09

23. Kazimirova K.O., Shtykov S.N. Sorbtsionnye I Khromatograficheskie Protsessy. 2023; 23(6): 980-992. (In Russ.) https://doi.org/10.17308/sorpchrom.2023.23/11859

24. Ho Y.S. J. Hazard. Mater. 2006; 136(3): 681-689. https://doi.org/10.1016/j.jhazmat.2005.12.043.

25. Shumilova M.A., Petrov V.G. Sorbtsionnye I Khromatograficheskie Protsessy.2022; 22 (2): 173-182. (In Russ.) https://doi.org/10.17308/sorpchrom.2022.22/9222

26. Crini G., Badot P.-M. Progress in Pol-ymer Science. 2008; 33: 399-447. https://doi. org/10.1016/j.progpolymsci.2007.11.001

27. Tran H.N., You S.-J., Hosseini-Bandegharaei A., Chao H.-P. Water Res. 2017; 120: 88-116. https://doi.org/10.1016/j.watres.2017.04.014

28. Ho Y.S., McKay G. Trans. I. Chem. E. 1998; 76: 332-340.

29. Hiew B.Y.Z., Lee L.Y., Lai K.C., Gan S., Thangalazhy-Gopakumar S., Pan G.-T., Yang T.C. Environ. Res. 2019; 168: 241-253. https://doi.org/10.1016/j.envres.2018.09.030

30. Allen S.J., McKay G., Khader K.Y.H. Environ. Pollut. 1989; 56: 39-50.

31. Cheung W.H., Szeto Y.S., McKay G. Bioresour. Technol. 2007; 98(15): 2897-2904. https://doi.org/10.1016/j.biortech.2006.09.045

32. Kruk M., Jaroniec M., Ko C.H., Ryoo R. Chem. Mater. 2000; 12: 1961-1968.

33. Ryoo R., Ko C.H., Kruk M., An-tochshuk V., Jaroniec M. J. Phys. Chem. B. 2000; 104: 11465-1147.

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Published

2026-08-26

Issue

Vol. 26 No. 2 (2026): Sorbtsionnye i Khromatograficheskie Protsessy

Section

Статьи

How to Cite

Sorption of nonsteroidal anti-inflammatory drugs from aqueous media by aluminosilicate ceramic microspheres. (2026). Sorbtsionnye I Khromatograficheskie Protsessy, 26(2), 375-385. https://doi.org/10.17308/sorpchrom.2026.26/14185

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