Signal amplification of piezoelectric immunosensor based on calix [6] arene for the determination of C-reactive protein using gold nanoparticles

Authors

  • Olga Yu. Shashkanova candidate of chemical science, associate professor of the chair of chemystry, Lipetsk State Technical University, Lipetsk
  • Elena V. Melihova candidate of chemical science, associate professor of the chair of chemystry, Lipetsk State Technical University, Lipetsk
  • Tatyana N. Ermolaeva doctor of chemistry, professor of the chair of chemistry, Lipetsk State Technical University, Lipetsk

Keywords:

Piezoelectric quartz immunosensor, C-reactive protein, Calix[6]arene, the gold nanoparticles, the amplification of the analytical signal.

Abstract

Gravimetric piezoelectric quartz immunosensor for the determination of C - reactive protein
(CRP) in liquid environments are developed. The conditions of the formation of a immunoaffinity coating
on the surface of the gold electrode sensor based on calix[6]arene and antibodies to C-reactive protein are
studied. The possibility of using gold nanoparticles to enhance the analytical signal of the sensor is
shown. Established, that the preliminary conjugation of gold nanoparticles with antibodies to CRP
contributes to lower detection limit CRP 0.02 to 0.006 microgram/ml.

Downloads

Download data is not yet available.

References

Downloads

Published

2019-11-21

Issue

Vol. 13 No. 5 (2013): Sorbtsionnye i Khromatograficheskie Protsessy

Section

Статьи

How to Cite

Signal amplification of piezoelectric immunosensor based on calix [6] arene for the determination of C-reactive protein using gold nanoparticles. (2019). Sorbtsionnye I Khromatograficheskie Protsessy, 13(5). https://journals.vsu.ru/sorpchrom/article/view/1697

Most read articles by the same author(s)

1 2 > >>