Perfluorinated membranes in pd-sensors for determination of components in dosage forms

Abstract

The influence of perfluorinated sulfonated cation-exchange polymeric membranes type on
the value of PD-sensors sensitivity (the response of PD-sensor is Donnan potential at the PSP
membrane/test solution interface) in aqueous solutions of nicotinic acid, pyridoxine hydrochloride,
novocaine hydrochloride, lidocaine hydrochloride was studied. The cross-sensitive PD-sensor with
pH-selective electrode and reference electrode was used for quantitative determination of vitamins
and pharmaceuticals in dosage forms. The multivariate calibration methods with nonorthogonal
experimental design were used for calibration of PD-sensors in polyionic solutions. The
calibration equations take into account the interference of organic electrolyte concentration and
рН of solution on the value of cross-sensitive PD-sensor. The relative error of determination of
substances in dosage forms was less than 8%.