Determination of valproic acid in serum using ion chromatography and capillary electrophoresis

Abstract

Ion chromatographic and capillary electrophoresis methods were developed for the
determination of valproic acid in serum after solvent extraction from serum. It was established that
capillary electophoresis allows to increase the expressity and sensitivity of valproic acid determination in
comparison with ion chromatography. Proposed methods have been applied to analysis of real samples of
patient’s sera from Military-Medical academy and Institute of cerebral (Saint Petersburg).