Magnetic separation as alternative extraction method of new classes doping substances from human urine

Authors

  • Irina I. Sukhanova researcher,Antidoping Centre, WADA Accredited Laboratory, Moskow, e-mail: i_sukhanova@mail.ru
  • Marina A. Dikunets eading scientist, PhD, Antidoping Centre, WADA Accredited Laboratory, Moskow
  • Eduard D. Virus leading scientist, PhD, Antidoping Centre, WADA Accredited Laboratory, Moskow
  • Timofey G. Sobolevsky head of laboratory, PhD, Antidoping Centre, WADA Accredited Laboratory, Moskow
  • Grigory M. Rodchenkov director, PhD, Antidoping Centre, WADA Accredited Laboratory, Moskow

Keywords:

Doping control, magnetic separation, selective androgen receptor modulator, peroxisome-proliferator activated receptor-δ, liquid-liquid extraction, solid phase extraction.

Abstract

New extraction procedure for the detection of doping substances was proposed. It is based on
magnetic separation with surface modified ferromagnetic micro-particles. The method for detection of the
new doping classes such as selective androgen receptor modulators (SARM) and peroxisome
proliferators-activated receptor agonists (РPARδ) was developed. Liquid-liquid and solid phase extraction
conditions of these doping substances were optimized. Comparison of three extraction methods was
performed. It was showed that magnetic separation can be used for doping control as alternative
extraction method prior to HPLC-MS/MS analysis

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Published

2019-11-22

Issue

Vol. 12 No. 2 (2012): Sorbtsionnye i Khromatograficheskie Protsessy

Section

Статьи

How to Cite

Magnetic separation as alternative extraction method of new classes doping substances from human urine. (2019). Sorbtsionnye I Khromatograficheskie Protsessy, 12(2). https://journals.vsu.ru/sorpchrom/article/view/1781