Analysis of pentoxifylline using matrix-assisted laser/desorption/ionsation, mass spectrometry

Authors

  • Kаrine R. Chamyan post-graduate student, Institution of Russian Academy of Science A.N. Frumkin Institute Of Physical Chemistry And Electrochemistry of RAS. Moscow, e-mail: kchamyan@gmail.com
  • Sergei A. Paramonov Dr. Sc. Chem., Institution of Russian Academy of Science A.N. Frumkin Institute Of Physical Chemistry And Electrochemistry of RAS, Moscow
  • Igor A. Revelsky Dr. Sc. Chem, Prof, Chemistry Department, Lomonosov Moscow State University, Moscow
  • Aleksey K. Buryak Chief of laboratory, Dr. Sc. Chem., Institution of Russian Academy of Science A.N. Frumkin Institute Of Physical Chemistry And Electrochemistry of RAS, Moscow

Keywords:

matrix-assisted laser/desorption/ionsation, mass spectrometry, pentoxifylline, analysis of pharmaceuticals.

Abstract

The possibility of pentoxifylline analysis using matrix-assisted laser/desorption/ionsation mass
spectrometry (MALDI MS) was investigated. Influence of matrix nature, sample preparation method and
laser settings on mass spectrocoric characteristics were studied. It was shown that MALDI MS allows to
analyze pentoxifylline at 8*10-15 level. Fragmentation pathways of protonated molecular ions were
studied using MALDI mass-spectrometry. The results were compared with respective literature data
received with electrospray ionisation

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Published

2019-11-26

Issue

Vol. 11 No. 5 (2011): Sorbtsionnye i Khromatograficheskie Protsessy

Section

Статьи

How to Cite

Analysis of pentoxifylline using matrix-assisted laser/desorption/ionsation, mass spectrometry. (2019). Sorbtsionnye I Khromatograficheskie Protsessy, 11(5). https://journals.vsu.ru/sorpchrom/article/view/1972

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