Isolation of geroprotective peptides from thymusamin (nucleoprotein complex from thymus)

Authors

  • Andrey Yu. Solovyev senior researcher, Institute of macromolecular compounds of RAS, St Petersburg. aslovo@yandex.ru
  • Dmitry V. Zhilinski graduate student, Institute of bioregulation and gerontology of the North- Western Branch of the Russian Academy of Medical Sciences, St Petersburg
  • Irina A. Chernova researcher, Institute of macromolecular compounds of RAS, St Petersburg
  • Vladimir Kh. Khavison prof., corr.member of the Russian Academy of Medical Sciences, director of Institute of bioregulation and gerontology of Western Branch of the Russian Academy of Medical Sciences , St Petersburg

Keywords:

nucleoprotein complex, cross-flow microfiltration, track etched membrane, solid phase extraction, regulatory peptides.

Abstract

Cross-flow microfiltration and selective adsorption of low molecular weight peptides on cation
exchanger Dowex 50-X8 were used for the preparative fractionation of nucleoprotein complex from
thymus. Peptide fraction were studied by gel chromatography, UV-spectroscopy, thin layer
chromatography and evaluation of biological activity by leukocyte migration inhibition factor. It is shown
that the peptide fraction from nucleoprotein complex includes components with molecular weights of 0.1
kDa to 3 kDa

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Published

2019-11-26

Issue

Vol. 11 No. 6 (2011): Sorbtsionnye i Khromatograficheskie Protsessy

Section

Статьи

How to Cite

Isolation of geroprotective peptides from thymusamin (nucleoprotein complex from thymus). (2019). Sorbtsionnye I Khromatograficheskie Protsessy, 11(6). https://journals.vsu.ru/sorpchrom/article/view/1990