Investigation of protein oligomerisation by gel permeation chromatography

Authors

  • Nina P. Kuznetsova Dr.Sci., the main scientific researcher, the Institute of Macromolecular Compounds RAS, St. Petersburg
  • Rimma N. Mishaeva Ph.D., senior researcher, the Institute of Macromolecular Compounds RAS, St.Petersburg
  • Lev R. Gudkin Ph.D., senior researcher, the Institute of Macromolecular Compounds RAS, St. Petersburg

Keywords:

polycondensation, protein oligomers, gel-penetrating chromatography, glutaraldehyde, hemoglobin, serum albumin.

Abstract

Роlycondensation of hemoglobin and serum albumin with glutaraldehyde was investigated. The
kinetics of pоlycondensation has been studied. The influence of component concentration and pH value
on process oligomerization of proteins was shown. The effect of the electrochemical state of the protein
macromolecule on formation of intermolecular bonds was determined. Oligomerization of proteins up to
high molecular products was shown to proceed in two stages

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Published

2019-11-26

Issue

Vol. 11 No. 6 (2011): Sorbtsionnye i Khromatograficheskie Protsessy

Section

Статьи

How to Cite

Investigation of protein oligomerisation by gel permeation chromatography. (2019). Sorbtsionnye I Khromatograficheskie Protsessy, 11(6). https://journals.vsu.ru/sorpchrom/article/view/1995

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