Determination of Quetiapine and it’s Metabolites and derivatives in biological samples by Gas-Liquid Chromatography – Mass Spectrometry and High Performance Liquid Chromatography

Authors

  • Aleksandra A. Mel`nik Forensic Medical Expert, Regional Bureau of Forensic Medical Examination, Chemical Department, Belgorod, Email chrzond@bel.ru
  • Andrei M. Grigor`ev Cand.Chem.Sci., Forensic Medical Expert, Regional Bureau of Forensic Medical Examination, Chemical Department, Belgorod
  • Lyubov` V. Azarova Forensic Medical Expert. Regional Bureau of Forensic Medical Examination, Chemical Department, Belgorod

Keywords:

quetiapine, metabolites, gas-liquid chromatography, mass-spectrometric detection, high-performance liquid chromatography.

Abstract

Advantages and restrictions of GLC-MS and HPLC-DAD methods are considered at
determination of metabolites and derivatives of quetiapine in biological liquids. The estimation of
thermolysis degree of dibenzotiazepine derivatives in GLC conditions is presented. GLC-MS properties
of the identified quetiapine metabolites and derivatives on two phases of different polarity are determined.
The presented variants of quantitative determination quetiapine by GLC-MS (as acetylated form) and
HPLC-DAD methods in biological liquids are based in liquid-liquid and solid-liquid extraction

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Published

2019-11-27

Issue

Vol. 10 No. 1 (2010): Sorbtsionnye i Khromatograficheskie Protsessy

Section

Статьи

How to Cite

Determination of Quetiapine and it’s Metabolites and derivatives in biological samples by Gas-Liquid Chromatography – Mass Spectrometry and High Performance Liquid Chromatography. (2019). Sorbtsionnye I Khromatograficheskie Protsessy, 10(1). https://journals.vsu.ru/sorpchrom/article/view/2018