Effect of synthesis conditions on specifity of polymeric sorbents imprinted with uric acid

Abstract

For optimizing the quantity of the introduced template molecules and increasing the specific
binding contribution to the sorption of uric acid by the molecularly imprinted sorbents, the main stages of
the conditions modification of the crosslinked polymeric system based on dimethylaminoethylene
methacrylate as functional monomers and ethyleneglycol dimethacrylate as a crosslinker synthesis were
studied. There were elaborated conditions for introducing the uric acid into the copolymerization bulk as
the well soluble salts of uric acid and organic bases. That permitted to increase the template molecules
concentration up to 16 mol % and to considerably increase the sorbent specific capacity. The modification
of the synthesis conditions also permitted to improve the sorbents biocompability properties in result of
excluding from the copolymerization bulk