Determination of monochloroacetic acid mass fraction in amidopropylbetaines by GC-MS analysis

Abstract

The target of the research were surfactants namely amidopropylbetaines commonly used in cosmetic
and medical products. Monochloroacetic acid and its inorganic salts which applied to amidopropylbetaines
production process have oral toxicity and irritation action that is exactly why it is necessary to control this
substances content in the product. Methodology of monochloroacetic acid quantification and its salts in
amidopropylbetaines was developed by GC-MS analysis with mass-selectively detector with application of
internal standard.
Methodology of analysis consists in transformation of monochloroacetic acid into methyl ester by
action of methanol in the presence of sulfuric acid by liquid-liquid microextraction and further gas
chromatographic definition with carbon tetrachloride as an internal standard.