Sorption phosphatidylcholine supersewed polystyrene in dynamic conditions

Abstract

The adsorption of phosphatidylcholine by hypercrosslinked polystyrene in dynamic conditions was
considered in present work. This paper discusses the possibility of effective solid phase extraction, precolumn
concentration and chromatographic separation of phospholipids using the structured polymeric
materials.
The sorption of phosphatidylcholine by hypercrosslinked polystyrenes (MN-102, MN-202) in the
dynamic conditions is examined. The experimental and theoretical breakthrough curves calculated by means
of adsorption Thomas model and asymptotic diffusional models are presented.
The mathematical models of sorption dynamics, taking into account the adsorption kinetics (Thomas
model) and mixed-diffusion (the external and internal diffusion limitation) gave opportunity to determine the
physicochemical parameters (equilibrium constants of adsorption, effective diffusion coefficients). The
comparison of experimental and theoretical breakthrough curves led to the conclusion that the asymptotic
model of sorption dynamics most adequately describes the adsorption of phosphatidylcholine by polymeric
sorbents. The asymptotic diffusional model appears to be a very useful tool for studies of sorption
mechanism as well as for process optimization and packed bed design of the system studied herein