Surface modification of channel microchip with electrochemical detection for the determination of biologically active substances

Authors

  • Andrey V. Nikolaev the post-graduate student of organic chemistry department of chemical faculty, St. Petersburg state university, St. Petersburg
  • Ludmila A. Kartsova Dr.Sc.Chem. the professor of organic chemistry department of chemical faculty, St. Petersburg state university, St. Petersburg, e-mail: kartsova@gmail.com

Keywords:

microchip capillary electrophoresis, microfluidics, electrochemical detection, electroosmotic flow, PDMS, analysis of neurotransmitters.

Abstract

The process of manufacturing of the chip-analyzer, based on polydimethylsiloxane is described.
The possibilities of surface treatment by atmospheric plasma as well as surfactants -sodium dodecyl
sulfate(SDS) and sodiumdeoxycholate, used as additives to the working 10 mM borate buffer are studied.
The change of the electroosmotic flow (EOF) is estimated. On the model mixture of catecholamines
changes in the efficiency and resolution of peaks after modification of the surface channels were assessed

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Published

2019-11-20

Issue

Vol. 13 No. 1 (2013): Sorbtsionnye i Khromatograficheskie Protsessy

Section

Статьи

How to Cite

Surface modification of channel microchip with electrochemical detection for the determination of biologically active substances. (2019). Sorbtsionnye I Khromatograficheskie Protsessy, 13(1). https://journals.vsu.ru/sorpchrom/article/view/1598

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