Joint determination of novocaine and lidocaine in aqueous solution using multisensory system
Keywords:
Donnan potential, potentiometric sensor, multisensory systems, medical substances, ion-exchange polymer, regression analyses.Abstract
Examines potentiometric multisensory systems that consist of novel cross-sensitive PDsensors.
The analytical signal of PD-sensors is the Donnan potential at the ion-exchange
polymer/electrolyte test solution interface. The analytical signal of PD-sensors is the Donnan
potential is developed for joint determination of novocaine, lidokaine in aqueous solution. For
organization PD-sensors perfluorinated sulphocation-exchange polymers (PSP) in H+- and K+-form were
used. Calculated values of sensitivity factor (S>25 mV/pC) and nonselectivity factor (F>0,5) was high.
Therefore PD-sensors can be used as cross-sensitive sensors for joint determination of systems
NovHCl+LidHCl. For graduation of separate sensors and analysis of the total response of sensor array
multivariate methods were used. The relative error of determination did not exceed 10 %.
