Определение каротиноидов методом ВЭЖХ, их антиоксидантная активность и влияние на здоровье человека (обзор)
Аннотация
Каротиноиды – широко распространенные соединения в пищевых продуктах. Их обнаружено около 1100, в значимых количествах в пище около 50, в плазме крови обнаружено 30 каротиноидов. Основные методы определения каротиноидов – это методы ВЭЖХ с разными детектирующими системами. Для идентификации каротиноидов используют методы ВЭЖХ с МС и МС-МС детекторами. С использованием методов ВЭЖХ созданы базы данных содержания каротиноидов в пищевых продуктах во многих странах Америки, Азии и Европы. За счет многих сопряженных связей (до 11) каротиноиды обладают антиоксидантной активностью.
Наибольшей антиоксидантной активностью обладает астаксантин, находящейся в красной рыбе, красной икре и креветках. За счет антиоксидантной активности каротиноиды обладают значительными оздоровительными эффектами. Регулярное потребление каротиноидов значительно снижает риск самых опасных болезней: сердечно-сосудистых, онкологических, диабета и др. Наибольшая смертность населения от этих болезней. Каротиноиды подавляют окислительный стресс-предшественник многих болезней, в т. ч. и самых опасных. Каротиноиды повышают иммунитет, убирают воспалительные процессы. Они эффективны при болезнях глаз и печени. Каротиноиды производят в мире в больших количествах, глобальный рынок более 1.5 млрд. долларов. Производятся в больших объемах: бета-каротин, ликопин, лутеин и астаксантин. По влиянию каротиноидов на здоровье человека опубликовано более 6000 научных работ.
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Литература
Dejneka V.I., Dejneka L.A., Anisi-movich I.P. Monografiya. Nomenklatura. Klassifikaciya. Sintez. Belgorod: IP Os-nashchenko A.A. 2011. 91 p. (In Russ.)
Karnauhov V.N. Biologicheskie funkcii karotinoidov. M. Nauka. 1988. 240 p. (In Russ.)
Strauh O. Key to carotenoids 2 nd ed Birkhauser Verlag. Basel. Switzerland 1987. 29
Siong T.E., Lam L.C. Analysis of Ca-rotenoids in Vegetables by HPLC. ASEAN Food Journal. 2019; 7(2); 91-996 p..
Rodriguez-Amaya D.B. A Guide to Carotenoid Analysis in Foods. ILSI Human Nutrition Institute. One Thomas Circle, NW, Washington DC, 20005-5802, 64 p.
Rodriguez-Amaya D.B., Kimura M. Harvest Plus. Handbook for carotenoids analysis. International Food Policy Re-search Institute. Washington D C. 2004. 58 p.
Vitamin A and Carotenoids: Chemis-try, Analysis, Function and Effects (Food and Nutritional Components in Focus, Vol-ume 1) 1st Edition by Victor R Preedy (Ed-itor), Royal Society of Chemistry; 1st edi-tion (August 30, 2012), 608 p.
Britton G., Liaaen-Jensen S., Pfander H. Carotenoids. Handbook Birkhauser. Verlag.Basel. Boston. Berlin. 2012. 885 p.
Zepka L.Q., Jacob-Lopes E., De Ros-so V.V. Progress in Carotenoid Research [Internet]. London: IntechOpen; 2018. 228 p.
Whitaker J. Carotenoids-Health benefits from A to Z. 2020. https://www.healthydirections.com/articles/eye-health/the-multiple-benefits-of-carotenoids?closebox=true
Carotenoids in Nature: Biosynthe-sis, Regulation and Function; Stange, C., Ed.; Springer: Cham, Switzerland. 2016; 79: 454 p.
Rodriguez-Concepcion M., Analos J. Bonet M.I. et al. A global perspective on carotenoids-metabolism, biotechnology and benefits for nutrition and health. Prog. Lipid. Res. 2018; 70: 62-93.
Eggersdorfer M., Wyss A. Carote-noids in human nutrition and health. Arch. Biochem.Biophys. 2018; 652: 18-26.
Finkel'shtejn E.I. Sovremennye metody analiza karotinoidov (Obzor). Himiko-farmacevticheskij zhurnal. 2016; 50: 29-40. (In Russ.)
Lako J. et al. Phytochemical flavonols, carotenoids. Food Chem. 2007; 101: 1727-1741.
Higuera-Ciapara I., Felix-Valenzuela L., Goycoolea F.M. Astaxanthin. A review of its chemistry and applica-tions. Crit. Rev. Food Sci. Nutr. 2006; 46: 185-196.
Hart D.J., Scott K.J. Development and evaluation on HPLC method for the analysis of carotenoids in foods and the measurement of the carotenoid content of vegetables and fruits commonly consumed in the UK. Food Chem. 1995; 54: 101-111.
Holden J.M., Sedridye A.L., Bee-cher G.R. et al. Carotenoid content of U.S foods. An update of the Database. J. Food Comp. Anal. 1999; 12: 169-196.
Heinonen M.I., Ollilainen V., Linkola E.K. et al. Carotenoids in Finnish foods. Vegetables, fruits and berries. J. Agric. Food Chem. 1989; 37: 655-699.
Marova L., Slovak B., Bilkova H. et al. Physiologically significant carotenoids and their common food sources in Czech population. Chem. Papers 1999; 53: 174-183.
Rodriguez-Amaya D.B. Updated Brasilian database on food carotenoids - factors affecting carotenoid composition. J. Food Compos. Anal. 2008; 21: 445-463.
Aizawa K., Inakuma T. Quantita-tion of carotenoids in commonly consumed vegetables in Japan. Food Sci. Nechnol. Res. 2007; 13: 247-252.
O Neill H.E., Carroll Y., Corrida B. et al. European carotenoid database to assess carotenoid intakes and its use in a five-country comparative study. Brit. J. Nutr. 2001; 85: 499-507.
Taylor K.L., Brackenridge A.E., Vivier M.A. et al. HPLC profiling of the major carotenoids in a rabidopsis thaliaka Ceaf. Tissue. J. Chrom A. 2006; 1121: 83-91.
Kotikova Z., Sule M., Lachman J. et al. Carotenoid profile and retention in yel-low, purple- and red fleshed potatoes after thermal processing. Food Chem. 2016; 197: 992-1001.
Kim J.S., An C.G., Park J.S. et al. Carotenoid profiling from 27 types of pap-rika with different colors, shapes and cultivation methods. Food Chem. 2016; 201: 64-71.
Shintani H. HPLC Analysis of vita-min A and carotenoids. Pharm. Anal. Acta. 2013; 4: 218-223.
Butnariu M. Methods of analysis (extraction, separation, identification and quatification) of carotenoids from natural products. J. Ecosystem Ecography. 2016; 8: 193-210.
Tee E.S. The analysis of carote-noids and retinoids - a review. Food Chem. 1991; 41: 147-193.
Rodriguez-Amaya D.B. Structures and analysis of carotenoid molecules. Sub-Cell Biochem. 2016; 79: 71-108.
Amorim-Currilho K.T., Cereda A., Fente C. et al. Review of methods for anal-ysis if carotenoids. Trends Anal. Chem. 2014; 56: 49-73.
Rivara S.M., Canela-Garayoa R. Analytical tools for the analysis of carote-noids in diverse materials. J. Chrom. A. 2012; 1224: 1-10.
Scott K.J. Observations on some of the problems associated with the analysis of carotenoids in foods by HPLC. Food Chrom. 1992; 45: 357-364.
van Brumen R.B. Liquid chroma-tography-mass spectrometry of carotenoids. Pure Appl. Chem. 1997; 69: 2061-2066.
Moros E.E., Darnoko D., Cheryan M. et al. Analysis of xanthophylls in corn by HPLC. J. Agric.Food Chem. 2002; 30: 5787-5790.
Dejneka V.I., Dejneka L.A. Inkrementnyj podhod v analize karotinoidov metodom OF VEZHKH. Razdelenie dief-irov ksantofillov. Sorbtsionnye I khromatograficheskie protsessy. 2006; 6(3): 366-375. (In Russ.)
Gupta P., Sreelakshmi Y., Sharma R. A rapid and sensitive method for determination of carotenoids in plant tissues by HPLC. Plant Methods 2015; 11: 5-9.
Dejneka V.I., Podkopajlo R.V., Dejneka L.A. Sorokopudov V.N., Gostishchev I.A. Opredelenie karotinoidov plodov oblepihi metodom VEZHKH. Nauchnye vedo-mosti Belgorodskogo gosu-darstvennogo universiteta. 2011; 15: 371-378. (In Russ.)
Zelenkova E.N., Egorova Z.E., SHabunya P.S., Fal'kova S.A. Analiz karotinoidov metodom VEZHKH v otdel'nyh sortah morkovi. Vestnik MAH. 2015; 4: 9-21. (In Russ.)
Kimura M. et al. Screening and HPLC methods for carotenoids in sweet-potato, cassava and maize for plant breed-ing trials. Food Chemistry. 2007; 100: 1734-1746.
Marinova D., Ribarova F.J. HPLC determination of carotenoids in Bulgarian berries. Journal of Food Composition and Analysis. 2007; 20: 370-374.
Pupin A.M., Dennis M.J., Toledo M.C.F. HPLC analysis of carotenoids in orange juice. Food Chem.1999; 64: 269-275.
Gleize B. et al. Simple and fast HPLC method for simultaneous determination of retinol, tocopherols, coenzyme Q10 and carotenoids in complex samples. Food Chem. 2012; 134: 2560-2564.
Dhankhar P., et al. Optimization of various steps for RP –HPLC determination of beta-carotene in milk fat. Intern. Food Res J. 2017; 24: 1393-1398.
Ligor M. Kovacova J. Buszewski B. Study of RP HPLC retention behaviors in analysis of carotenoids. Chromatographia. 2014; 77: 1147-1157.
Rasavi S.H., Blanchard F., Mare I. UV-HPLC-APCI-MS method for separation and identification of the carotenoids produced by sporobolomyces ruberrimus H110. Iran. J. Chem.Chem. Eng. 2006; 25: 32-36.
Barba A.O. et al. Application of a UV-VIS detection HPLC method for a rapid determination of lycopene and beta-carotene in vegetables. Food Chemistry. 2006; 95: 328-336.
Rivera S.M., Christou P. Identification of carotenoids using mass spectrometry. Mass spect. Rev. 2014; 33: 353-372.
Daood H., Bencze G., Pelotos G., Pak Z. HPLC analysis of carotenoids from tomatoes using cross-linked C18 column and MS detection. J. Chrom. Sci. 2014; 52: 985-991.
Hrvalova B., Martinez-Hullamo M. et al. Development of an advanced HPLC – MS/MS method for the determination of carotenoids and fat-soluble vitamins in human plasma. Int. J. Mol. Sci. 2016; 17: 1719-1725.
Bizzo H.R., Faria-Machado A.F., Guedes A.M. et al. Simultaneous determination of carotenoids and tocochromanols from palm hybrid oil by HPLC with photodiode array and fluorescence detectors. Li-pids. 1992; 27: 483-490.
Ferruzzi M.G., Sander L.C., Cocu C.L. et al. Carotenoid determination in bio-logical microsamples using liquid chroma-tography with coulometric electrochemical array. Anal. Biochem.1998; 256: 74-81.
Gamache P., Acworth I. Measurement of dietary carotenoid isomers using HPLC-ECD. Thermo-Fischer Scientific. Application Brief 162. 2016; 1-4.
Zeb A. A simple, sensitive HPLC-DAD method for simultaneous determination of carotenoids, chlorophylls and alfa-tocopherol in leafy vegetables. Food meas-ure. 2017; 11: 979-986.
Kurz C., Carle R., Schieber A. HPLC-DAD-MS(n) characterisation of carotenoids from apricots and pumpkins for the evaluation of fruit product authenticity. Food Chem. 2008; 110: 522-530.
Strohschein S., Pursch M., Handel H., Albert K. Structure elucidation of beta-carotene isomers by HPLC-NMR coupling using a C30 bonded phase. Fres. J. Anal. Chem. 1997; 357: 998-502.
Bohoyo-Gil D., Dominguez-Valhondo D. et al. UHPLC as suitable methodology for the analysis of caron-enoids in food matrix. Eur. Food Res. Techn. 2012; 235: 1055-1061.
Pauni T., Fu W., Gudmundsson S. et al. Multidimensional analytical approach based on UHPLC-UV-ion mobility MS for the screening of natural products. Anal. Chem. 2015; 87: 2593-2599.
Cacciola F., Donato P., Guiffrido D. et al. Ultra high pressure in the second dimension of a comprehensive two-dimension liquid chromatography system for carotenoid separation in red chili peppers. J. Chrom. A. 2012; 1255: 244-251.
Jeffrey S.W. An improved thin-layer chromatographic technique for marine phytoplankton pigments. Limnol. Cre-anogr. 1981; 26: 191-197.
Kuregyan A.G. Izuchenie karoti-noidov tykvy metodami spektrofotometrii i tonkoslojnoj hromatografii. Sovremennye problemy nauki i obrazovaniya. 2015; 1-2. (In Russ.)
Lander W.O., Eitenmiller R.R. Ap-plication of gel permeation chromatography and nonaqueous reverse phase chromatography to high pressure liquid chromatography determination of retinyl palmitate and beta-carotene in oil and margarine. J AOAC 1979; 62: 283-289.
Donato P., Cacciola F., Mondello L et al. Analysis of the carotenoid composition and stability in various overripe fruits by comprehensive two-dimensional liquid chromatography. LC GC Europe. 2016; 29: 252-257.
Pfander H., Riesen R., Niggli U. HPLC and SFC of carotenoids-scope and limitations. Pure Appl. Chem.1994; 66: 947-954.
Balomon M.Y., Piccoli P., Fountana A. Simultaneous determination of carotenoisa with different polarities in tomato products using a C30 coreshell column based approach Microchemical J. 2020; 159: 105390.
Bell C.M., Sander L.C., Wise S.A. Temperature dependence of carotenoids on C18, C30 and C34 bonded stationary phases. J. Chrom. 1997; 757: 29-39.
Adadi P., Barakova N.V., Krivosh-apkina E.F. Selected methods of extraction carotenoids, characterization and health concerns. A review. J. Agric. Food Chem. 2018; 66: 5925-5947.
Montesano D. et al. A simple and selective analytical procedure for the extraction and quantification of lutein from tomato by products by HPLC-DAD. Food Anal. Methods. 2012; 5: 710-715.
Pacheco S., Peixoto F.M., Borguini R.G. et al. Microscale extraction method for a HPLC carotenoids analysis in vegetable matrics. Scientia Agricola. 2014; 71: 345-355.
Saini R.K., Keum Y. Carotenoid ex-traction methods. A review of recent developments. Food Chem. 2018; 240: 90-103.
Poojary M.M., Barba F.J., Aliakbarian B. et al. Innovative alternative technologies to extract carotenoids from microalgae and seeweeds. Marine Drugs 2016; 14: 214-221.
Ganzler K., Salgo A., Valko K. Microwave extraction. A novel simple preparation method for chromatography. J. Chrom. 1986; 371: 299-306.
Petry F.C., Mercadante A.Z. New method for carotenoid extraction and analysis by HPLC-DAD-MS/MS in freezedried citrus and mango pulps. J. Brasz. Chem. Soc. 2018; 29: 205-215.
Palva S.A., Russell R.M. Beta-carotene and other carotenoids as antioxidants. J. Am. Coll. Nutr. 1999; 18: 426-433.
Krinsky N.I. Carotenoids as antiox-idants. Nutrition. 2001; 17: 815-817.
Stahl W., Sies H. Antioxidant activ-ity of carotenoids. Mol. Aspect. Med. 2003; 24: 345-351.
Igielska-Kalwat J., Goscianska J., Nowak I. Carotenoids as natural antioxidants. Postepy Hig. Med. Dosw (online). 2015; 69: 418-428.
Kiokias S., Gordon M. Antioxidant properties of annatto carotenoids. Food Chem. 2003; 83: 523-529.
Rodriguez-Amaya D.B. Quantitative analysis, in vivo assessment of bioavailability and antioxidant activity of food carotenoids. A review. J. Food Composi-tion and Analysis. 2010; 23: 726-740.
Palozza P., Krinsky N.I. Antioxi-dant effects of carotenoids in vivo and in vitro. An overview. Meth. Enzymol. 1992; 213: 403-420.
Miller N.J., Sompson J., Candeias l. P. et al. Antioxidant activities of carotene and xanthophylls. FEBS Lett. 1996; 384: 240-242.
Gusman I., Vargas K., Chacon F. et al. Health-promoting carotenoids and phe-nolics in 31 capsicum accessions. Amer. J. Horticultural Sci. 2021; 56: 36-41.
Rao A.V., Rao L.G. Carotenoids and human health. Pharm. Res. 2007; 55: 207-216.
Krinsky N.L., Johnson E.J. Carote-noids actions and their relation to health and disease. Mol. Asp. Med. 2005; 26: 459-516.
Olson J.A. Carotenoids and human health. Arch. Latinoaver. Nutr. 1999; 49: 73-81.
Fiedor J., Burda K. Potential role of carotenoids as antioxidants in human health and disease. Nutrients. 2014; 6: 466-468.
Tapiero H., Townsend D.M., Tew K.D. The role of carotenoids in the prevention of human pathologies. Biomed. Phar-macother. 2004; 58: 100-110.
Lia Z. Potential role of carotenoids as antioxidants in human health and dis-ease. Curr. Pharm. Design. 2017; 5: 1-10.
Fassett R.G., Coombes J.C. Astaxanthin in cardiovascukar health and disease. Molecules. 2012; 17: 2030-2048.
Riccioni G., D Orazio N. et al. Ma-rine carotenoids and cardiovascular risk markers. Mar. Drugs. 2011; 9: 1166-1175.
Di Pietro N., Di Tomo P., Pandolf A. Carotenoids in cardiovascular disease prevention. JSM Atheroscler. 2016; 1: 1102-1109.
Tanaka T., Shinimizu M., Morivaki H. Cancer chemoprevention by carotenoids. Molecules. 2012; 17: 3202-3242.
Soares N., Teodoro A.J., Cotsch P.R. et al. Anticancer properties of carotenoids in prostate cancer. A review. Histol. Histopathol. 2015; 30: 1143-1154.
Smith T.A.D. Carotenoids and can-cer prevention and potential therapy. Brit. J. Biomed. Sci. 1998; 55: 265-268.
Collins K. Cancer reducing risk with carotenoids. Today’s dietitian.2019; 21: 12-21.
Kiokias S., Gordon M. Dietary supplementation with a natural carotenoids mixture decreases oxidative stress. Eur. J. Clin. Nutr. 2003; 57: 1135-1140.
Gammone M.A., Riccioni G., D Orazio N. Marine carotenoids against oxidative stress. Effects on human health. Mar. Drugs. 2015; 13: 6226-6246.
Chen B.P., Park J.S. Carotenoids ac-tion on the immune response. J. Nutr. 2004; 134: 257-261.
Sluijs I., Cadier E., Benlens J.W. et al. Dietary intake of carotenoids and risk of type 2 diabetes. J. Nutr. Metab. Cardivasc. Dis. 2015; 25: 275-282.
Snodderly D.M. Evidence for pro-tection against age-related macular degeneration by caronenoids and antioxidant vit-amins. Am. J Clin. Nutr. 1995; 62: 1448-1461.
Shidfar F., Agah S., Ekhlasi G. et al. Lycopene as adjunctive therapy for Helicobacter pylori eradication-a quasi-control trial. J. Complement. Integr. Med. 2012; 9: 14-21.
Christensen K., Lowler T., Mares J. Dietary Carotenoids and Non-Alcoholic Fatty Liver Disease among US Adults, NHANES 2003-2014. Nutrients. 2019; 11: 1101-1108.
Mounien L., Tourniase F., Landrier J.F. Anti-obesity effect of carotenoids-direct impact on adipose tissue and adipose tissue-driven indirect effects. Nutrients. 2019; 11: 1562-1567.
Rao A.V., Agarwal S. Role of lycopene as antioxidant carotenoids in the prevention of chronic disease. A review. Nutr. Res. 1999; 19: 305-323.
Stephen I.D., Coetzee P., Perrett D.I. Carotenoids and melanin pigment coloration affect perceived human health. Evolution and human behavior. 2011; 33: 216-227.
