Use of Solid Dispersion Systems in Pharmacy

Abstract

An overview of the use of solid dispersion systems in pharmacy is presented. The main techniques of obtaining solid dispersions were considered. The simplest one is the solvent removal technique: the medicinal drug and the carrier are dissolved in the solvent that is then evaporated. The fusion method involves heating the mixture of the medicinal drug with the carrier above the fusion temperature with further hardening under quick cooling. The co-milling method is based on the co-use of compression, fracture, and friction energy for the transition of the solid-state drug and carrier into the
amorphous state. The kneading method is a variation of the co-milling method. In this case, the solvent performs several functions at the same time: it dissolves one of the components and enters the micro-fi ssures of crystals of another component, producing a wedge effect and contributing to the milling and interpenetration of one substance into the pores of another. The method of using the agents stabilising the amorphous state of the medicinal drug involves mixing the following components: a sparingly soluble medicinal drug, an agent inducing the transition of the system into the amorphous state, and an agent stabilising its amorphous state. The obtained mixture is subjected to thermal or mechanochemical treatment. Combinations of these methods are also used to obtain solid dispersion systems. Examples of polymers and non-polymer substances used as carriers in solid dispersion systems are given. The works of authors were studied that are dedicated to the creation and study of solid dispersions of various active pharmaceutical ingredients as well as dosage forms produced from these solid dispersions.

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