Adsorption of eremomycin on the walls of fused silica and modified capillaries in the process of electrophoretic separation of aromatic acid enantiomers

Authors

  • Margarita V. Lebedeva postgraduate student (1st year of studies), Analytical Chemistry division, Chemistry Department, M.V. Lomonosov Moscow State University, Moscow, e-mail: margoL87@mail.com
  • Aleksandra F. Prokhorova junior researcher, Analytical, Chemistry Department, M.V. Lomonosov Moscow State University, Moscow
  • Elena N. Shapovalova associate professor, Analytical Chemistry division, Chemistry Department, M.V. Lomonosov Moscow State University, Moscow
  • Oleg A. Shigun corresponiding member of Russ. Acad. Sci., Head of the Chromatography Laboratory, Analytical Chemistry division, Chemistry Department, M.V. Lomonosov Moscow State University, Moscow
  • Sergei M. Staroverov Head of the Laboratory of new chemical technologies for medicine, Chemical Enzymology division, Chemistry Department, M.V. Lomonosov Moscow State University, Moscow
  • Mikhail A. Kuznetsov senior researcher, Chemical Enzymology division, Chemistry Department, M.V. Lomonosov Moscow State University, Moscow

Keywords:

coated capillaries, eremomycin, adsorption.

Abstract

Methods for the preparation of fused-silica capillaries coated with chitosan, 3-
aminopropyltrimethoxysilane, 3-glicidoxypropyltriethoxysilane and eremomycin were offered. It was
found that the most stable coating consisted of eremomycin covalently bonded to the silica surface
through 3-glicidoxypropyltriethoxysilane. The adsorption of eremomycin on the capillary surface was
studied. It was shown that capillary coating reduced the eremomycin adsorption. To reduce this
phenomenon, the 3-aminopropyltrimethoxysilane-coated capillary was shown to be more effective than
that with eremomycin immobilized through 3-glicidoxypropyltriethoxysilane. Four profens were
enantioseparated in coated capillaries using as less as 1 mM eremomycin

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Published

2019-11-26

Issue

Vol. 11 No. 5 (2011): Sorbtsionnye i Khromatograficheskie Protsessy

Section

Статьи

How to Cite

Adsorption of eremomycin on the walls of fused silica and modified capillaries in the process of electrophoretic separation of aromatic acid enantiomers. (2019). Sorbtsionnye I Khromatograficheskie Protsessy, 11(5). https://journals.vsu.ru/sorpchrom/article/view/1965

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