High performance liquid chromatography in the quantitative analysis of hydroxycinnamic acids in plants growing in the Russian Federation
Abstract
Currently, high performance liquid chromatography method has a leading position in drug quality control and study of plant material. In recent years, a large amount of information on the study of plants growing or cultivated on the territory of the Russian Federation for the identification of hydroxycinnamic acids has been accumulated. The purpose of this review is systematization of information on the use of high performance liquid chromatography method for the determination of the quantitative content of hydroxycinnamic acids in plants growing or cultivated on the territory of the Russian Federation. The systematization of scientific research published in scientific journals and abstracts of conferences performed in the Russian Federation was performed. The analysis of these studies showed that Russian scientists over the past 15 years started widely use the HPLC method for the determination of the quantitative content of hydroxycinnamic acids in plant material. Almost all studies were performed using foreign equipment, and mobile phases of solvents were successfully used in the analysis for both isocratic and gradient elution modes. The results of the search of hydroxycinnamic acids in plant raw material of about 150 plant species were published 50 literature sources. Grass or leaves of plants were mainly used as raw material, and chlorogenic acid was found in almost all the plants studied. The highest amount of chlorogenic acid was find in fruits of some Berberis species, leaves ofParasenecio hasstatus (L.) H. Koyama, Nepeta cataria L. leaves , Galeopsis bifida L. grass , Cynara cardunculus L. leaves. Plants containing rosmarinic acid – Prunella vulgaris L., Prunella laciniata (L.) L., Majorana hortensis, Mentha spicata L., Artemisia santonica, Origanum vulgare and plants containing caffeic acid - Arctium tomentosum Mill. leaves are also promising. In the gradient elution mode, the content of hydroxycinnamic acids in Prunella vulgaris L., P. laciniata (L.) L. and P. grandiflora (L.) Turra. was determined. At the same time, the proportion of solution B (a mixture of acetonitrile - methanol - water with perchloric acid in a ratio of 40:40:20, pH 2.5) in a mixture with solution A (an aqueous solution of perchloric acid, pH 1.8) increased from 0% to 100% during 80 minutes at 30°C. Caffeic acid (traces) and rosmarinic acid (up to 2.9%) were found [33].
These plants can serve as potential sources for the creation of new highly effective drugs. However, for this purpose it is necessary to have data on the dynamics of accumulation of hydroxycinnamic acids depending on the season, place of growth, terms and conditions of harvesting, storage of the plant. In the absence of such data, studies aimed at normalization of the amount of hydroxycinnamic acids in potential plant raw material with high content are required.
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References
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