Influence of the structure of benzimidazoles on their retention by octadecyl silica gel under conditions RP HPLC
Abstract
The identification of the relationship «structure-property» is one of the priority areas of physics and
chemistry, as the results of such studies allow to predict properties of new compounds and conduct their directed
synthesis. The most relevant such studies for compounds having biological activity and which are the
main components of new or existing drugs. On the basis of such studies by regression analysis are the correlation
«structure-retention-property», allowing to predict the properties of compounds. To improve the
predictive ability of these equations using multivariable linear regression models. In the work with the use of
reversed-phase high-performance liquid chromatography (RP HPLC) to study the effect of structure of some.
their chromatographic retention on octadecylsilane of water-methanol eluent. It is shown that the sorption
volume of the benzimidazole molecules strongly affects the conformational mobility of these structures.
Using linear regression analysis of the obtained one-, two - and three-parameter correlation equations; it is
shown that the most complete chromatographic retention can be described with the use of three-parameter
equations containing volume, the surface area of the molecule and principal moment of inertia of the
molecules along the Z-axis (Izz). The obtained results can be used to predict the retention of substances
belonging to this class of organic compounds
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References
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