Chromato-mass-spectrometric analysis of the reaction between 1,2-diaminoimidazole and 1-aryl-3-(dimethylamino)prop-2-en-1-one
Abstract
Diaminoimidazoles are actively used in the creation of various substances with a given physiological
activity. However, the main problem in the chemistry of this polynucleophilic substrate is: the determination
of the sequence of transformations leading to final products during various cascade processes, as well as
the time that is necessary to form the maximum number of desired substances. By the method of highperformance
liquid chromatography in combination with mass spectrometry, we studied the interaction of
1,2-diaminoimidazole with 1-phenyl-3-(dimethylamino)prop-2-en-1-one. In the course of the analysis, it was
found that the reaction takes place over two hours of boiling and leads to a single product - 4-phenyl-5-
phenylimidazo[1,5-b]pyridazine-7-amine.
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References
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