Study of thermodynamic of certain benzimidazole derivatives sorption from water – methanol solutions on hexadecyl silica gel
Abstract
The investigation of sorption from liquid solutions is an actual direction of modern science, both for the development of the fundamental foundations of the theory of sorption, and for the development of effective sorbents. The key aspect in the research of various structural classes compounds sorption is to analyze the relationship between structure and property, in which the influence of the structure of the compound on its sorption characteristics is manifested. Benzimidazoles and its derivatives are component part of an large amount of medications, therefore the investigation of their sorption from liquid solutions allows to determine the dynamics of their effect on the body and pharmacokinetics; to find methods of their eluting from biological fluids and to select the optimal conditions for extracting investigating compounds.
The experiment was carried out on a liquid chromatograph «MiliChrom A-02» with the UV spectrophotometric detector and a syringe pump in reversed-phase mode, using water methanol solutions as the eluent. The aim of this work was to analysis the benzimidazole derivatives sorption from various quantitative composition of water-methanol solutions, to determine the thermodynamic characteristics of sorption, and to establish the relationship «structure-property» within the framework of the Snyder-Sochevinsky model.
In this paper, the effect of the composition of water methanol solution on benzimidazoles sorption on the surface of hexadecyl silica gel was studied. The corresponding equations were obtained within the framework of the Snyder-Sochevinsky model. The energy contribution of different substituting groups in sorption process was estimated by applying Gibbs energy differences. The enthalpy and entropy component of sorption process were calculated and compensations for the bendimidazole derivatives on mobile phases with different contents of the organic modifier were studied. Indicated that two groups of sorbates are isolated on the phase with 80% methanol content as it was connected with their different sorption mechanisms on hexadecylsilica gel.
Downloads
References
2. Konstantinov A. V., Shafigulin R. V., Il'in M. M., Davankov V. A., Bulanova A. V,. Purygin P.P Sorbcija nekotoryh izatinov na razlichnyh sorbentah v uslovijah OF VJeZhH, Russian Journal of Physical Chemistry A, 2013, T. 87, № 6, P. 1049–1052
3. Shafigulin R. V., Safronova I.A., Krasnova M.S., Bulanova A.V., Fizikohimija poverhnosti i zashhita materialov, 2015, Vol. 51, No 3, pp. 263-268.
4. Shafigulin R.V., Myakishev A.A., Il’ina E.A., Il’in M.M. et al., Russian Journal of Physical Chemistry A, 2011, Vol. 85, No 7, pp. 1216-1221.
5. Rakesh K. Patel, Vishal R. Patel, Madhavi G., Journal of Pharmaceutical Analysis, 2012, Vol. 2, Iss. 5, pp. 366-371.
6. Abolfazl Rahmani-Sani, Ahmad Hosseini-Bandegharaei, Seyyed-Hossein Hosseini et al., Journal of Hazardous Materials, 2015, Vol. 286, pp. 152-163.
7. Hosseini-Bandegharaei A., Hosseini M.S., Jalalabadi Y., Sarwghadi M. et al., Intern. J. Environ. Anal. Chem, 2013, Vol. 93, pp. 108-124.
8. Shafigulina A.D., Larionov O.G., Revina A.A., Ponomarjov K.V. et al., Sorbtsionnye i khromatograficheskie protsessy, 2013, T. 13, № 6, P. 920-927
9. Shatc V.D., Sahartova O.V., Vysokojeffektivnaja zhidkostnaja hromatografija: Osnovy teorii. Metodologija. Primenenie v lekarstvennoj himii , Riga, Zinatne, 1988, 390 p.
10. Konstantinov A.V. Diss. cand. chem. nauk. Saratov, 2013, 22 p.
11. Bulanova A.V., Poljakova Ju.L. Hromatografija v medicine i biologii: uchebnoe posobie Feder. agenstvo po obrazovaniju. Samara, Izd-vo «Samarskij universitet», 2006, 116 p.
12. Sorokin A.A., Gar'kin V.P., Eliseeva E.V., Red'kin N.A. et al., Sorbtsionnye i khromatograficheskie protsessy 2014, Vol. 14, No 4, pp. 555-562.
13. Shafigulin R.V., Bulanova A.V., Journal of Physical Chemistry A, 2018, Vol. 92, No 2, pp. 202-208.
14. Krug R.R., Hunter W.G., Grieger R.A., J. Phys. Chem, 1976, Vol. 80, pp. 2335.
15. Neckina O.V. Adsorbcija iz rastvorov na tverdoj poverhnosti, Novosibirsk, NGU, 2015, 17 p.
16. Shafigulin R.V., Konstantinov A.V., Bulanova A.V., Il'in M.M. et al., Russian Journal of Physical Chemistry A, 2016, Vol. 90, No 11, pp. 1729-1733.
