Gender differences in lipid metabolism

  • Valentina O. Mittova Voronezh State Medical University named after N. N. Burdenko of the Ministry of Health of the Russian Federation, 10 Studencheskaya str., Voronezh 394036, Russian Federation https://orcid.org/0000-0002-9844-8684
  • Anna O. Khoroshikh Voronezh State Medical University named after N. N. Burdenko of the Ministry of Health of the Russian Federation, 10 Studencheskaya str., Voronezh 394036, Russian Federation https://orcid.org/0000-0001-9953-2653
  • Olga V. Zemchenkova Voronezh State Medical University named after N. N. Burdenko of the Ministry of Health of the Russian Federation, 10 Studencheskaya str., Voronezh 394036, Russian Federation https://orcid.org/0000-0003-1996-9500
  • Sergey V. Ryazantsev Voronezh State Medical University named after N. N. Burdenko of the Ministry of Health of the Russian Federation, 10 Studencheskaya str., Voronezh 394036, Russian Federation https://orcid.org/0000-0002-0839-103X
  • Oleg V. Maslov Voronezh State Medical University named after N. N. Burdenko of the Ministry of Health of the Russian Federation, 10 Studencheskaya str., Voronezh 394036, Russian Federation https://orcid.org/0000-0001-9476-2695
  • Elena V. Korzh Voronezh State Medical University named after N. N. Burdenko of the Ministry of Health of the Russian Federation, 10 Studencheskaya str., Voronezh 394036, Russian Federation https://orcid.org/0000-0002-1788-2818
  • Lilia S. Ryasnaya-Lokinskaya Voronezh State Medical University named after N. N. Burdenko of the Ministry of Health of the Russian Federation, 10 Studencheskaya str., Voronezh 394036, Russian Federation https://orcid.org/0000-0002-5179-7086
  • Vladimir V. Alabovsky Voronezh State Medical University named after N. N. Burdenko of the Ministry of Health of the Russian Federation, 10 Studencheskaya str., Voronezh 394036, Russian Federation https://orcid.org/0000-0002-6306-5149
Keywords: Lipid metabolism, Atherosclerosis, Metabolic syndrome, Cholesterol, Triglycerides, LDL, HDL, ApoV / ApoA1, Atherogenic coefficient

Abstract

The search for early markers of atherosclerosis is an effective method for providing personalized medicine allowing the prevention of the progression of this pathology. The aim of this study was the determination of the total indices of dyslipidemia and the identification of the gender indices of the extended lipid profile in the population of residents of the Southern and Central Federal Districts (Voronezh, Belgorod, Lipetsk, Kursk and Rostov regions) for the identification of early markers of atherogenicity. In a simultaneous clinical study, involving 339 patients (mean age 48 years), the concentrations of total cholesterol, triglycerides, LDL (low density lipoproteins), HDL (high density lipoproteins), apolipoproteins B and A1, the ApoB/ApoA1 ratio and the atherogenic coefficient were determined. For the identification of the relationship between changes in lipid profile indicators with cytolysis syndrome and indicators of carbohydrate metabolism, the activity of ALAT (alanine aminotransferase), GGTP (gamma-glutamyl transpeptidase) and glucose content
were also studied. Analysis of the results of the lipid spectrum of the population sample of the middle age group revealed significant metabolic disorders of lipid metabolism with a predominance of atherogenic lipid fractions and a significant excess of indicators of atherogenic lipid fractions in middle-aged men in  comparison with women. It has been shown that the apoB/apoA1 index can be used as an auxiliary marker for early assessment of the prevalence of atherogenic lipid fractions, allowing the identification of risk groups for the development of diseases associated with metabolic disorders

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Author Biographies

Valentina O. Mittova, Voronezh State Medical University named after N. N. Burdenko of the Ministry of Health of the Russian Federation, 10 Studencheskaya str., Voronezh 394036, Russian Federation

PhD in Biology, Assistant
Professor of the Department of Biochemistry,
Voronezh State Medical University named after N. N.
Burdenko of the Ministry of Health of the Russian
Federation, Voronezh, Russian Federation; e-mail:
vmittova@mail.ru

Anna O. Khoroshikh, Voronezh State Medical University named after N. N. Burdenko of the Ministry of Health of the Russian Federation, 10 Studencheskaya str., Voronezh 394036, Russian Federation

student of the General
Medicine Faculty, Voronezh State Medical University
named after N. N. Burdenko of the Ministry of Health
of the Russian Federation, Voronezh, Russian
Federation; e-mail: anna.horoshih@gmail.com

Olga V. Zemchenkova, Voronezh State Medical University named after N. N. Burdenko of the Ministry of Health of the Russian Federation, 10 Studencheskaya str., Voronezh 394036, Russian Federation

PhD in Biology, Teaching
Assistant of the Department of Biochemistry, Voronezh
State Medical University named after N. N. Burdenko
of the Ministry of Health of the Russian Federation,
Voronezh, Russian Federation; e-mail: zov-bio@mail.ru

Sergey V. Ryazantsev, Voronezh State Medical University named after N. N. Burdenko of the Ministry of Health of the Russian Federation, 10 Studencheskaya str., Voronezh 394036, Russian Federation

PhD in Biology, Teaching
Assistant of the Department of Biochemistry, Voronezh
State Medical University named after N. N. Burdenko
of the Ministry of Health of the Russian Federation,
Voronezh, Russian Federation; e-mail: ryazantsev77@gmail.com

Oleg V. Maslov, Voronezh State Medical University named after N. N. Burdenko of the Ministry of Health of the Russian Federation, 10 Studencheskaya str., Voronezh 394036, Russian Federation

PhD in Biology, Assistant Professor
of the Department of Biochemistry, Voronezh State
Medical University named after N. N. Burdenko of the
Ministry of Health of the Russian Federation,
Voronezh, Russian Federation; e-mail: maslovoleg1205@mail.ru

Elena V. Korzh, Voronezh State Medical University named after N. N. Burdenko of the Ministry of Health of the Russian Federation, 10 Studencheskaya str., Voronezh 394036, Russian Federation

PhD in Medicine, Assistant
Professor of the Department of Obstetrics and
Gynaecology no. 1, Voronezh State Medical University
named after N. N. Burdenko of the Ministry of Health of the Russian Federation, Voronezh, Russian
Federation; e-mail: elenakorzh2012@mail.ru

Lilia S. Ryasnaya-Lokinskaya, Voronezh State Medical University named after N. N. Burdenko of the Ministry of Health of the Russian Federation, 10 Studencheskaya str., Voronezh 394036, Russian Federation

PhD student of the
Department of Hospital Therapy and Endocrinology,
Resident Physician of Voronezh State Medical
University named after N. N. Burdenko Ministry of
Health of the Russian Federation, Voronezh, Russian
Federation; e-mail: lokinskaya@rambler.ru

Vladimir V. Alabovsky, Voronezh State Medical University named after N. N. Burdenko of the Ministry of Health of the Russian Federation, 10 Studencheskaya str., Voronezh 394036, Russian Federation

DSc in Medicine, Professor,
Head of the Department of Biochemistry, Voronezh
State Medical University named after N. N. Burdenko
of the Ministry of Health of the Russian Federation,
Voronezh, Russian Federation; e-mail: v.alabovsky@yandex.ru

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Published
2021-06-04
How to Cite
Mittova, V. O., Khoroshikh, A. O., Zemchenkova, O. V., Ryazantsev, S. V., Maslov, O. V., Korzh, E. V., Ryasnaya-Lokinskaya, L. S., & Alabovsky, V. V. (2021). Gender differences in lipid metabolism. Kondensirovannye Sredy I Mezhfaznye Granitsy = Condensed Matter and Interphases, 23(2), 245-259. https://doi.org/10.17308/kcmf.2021.23/3436
Section
Original articles