Гендерные особенности липидного обмена
Аннотация
Поиск ранних маркеров атеросклероза является эффективным методом персонализированной медицины, способствующей предупреждению прогрессирования данной патологии. Целью данной работы было определение суммарных показателей дислипидемии и выявление гендерных показателей расширенного липидного профиля в популяции жителей Южного и Центрального Федеральных округов (Воронежская, Белгородская, Липецкая, Курская и Ростовская области) для идентификации ранних маркеров атерогенности. В клиническом исследовании, проводимом одномоментно, у 339 пациентов (средний возраст 48 лет) были определены концентрации общего
холестерина, триглицеридов, ЛПНП (липопротеинов низкой плотности), ЛПВП (липопротеинов высокой плотности), аполипопротеинов В и А1, соотношение АпоВ/АпоА1 и коэффициент атерогенности. Для выявления взаимосвязи изменения показателей липидного профиля с синдромом цитолиза и показателями углеводного обмена у пациентов также исследовали активность АЛАТ (аланинаминотрансферазы), ГГТП (гамма-глутамилтранспептидазы) и
содержание глюкозы. Анализ результатов липидного спектра популяционной выборки средней возрастной группы выявил значительные метаболические нарушения липидного обмена с преобладанием атерогенных фракций липидов и значительное превышение показателей атерогенных фракций липидов у мужчин средней возрастной категории в сравнении с женщинами. Показано, что показатель апоВ/апоА1 может использоваться как вспомогательный маркер для ранней оценки преобладания атерогенных фракций липидов, что позволяет выделять
группы риска в отношении развития заболеваний, связанных с метаболическими нарушениями
Скачивания
Литература
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