Chromatographic separation of itaconic anhydride recycling products with 5-amino-1-phenylpyrazoles
Abstract
An important role in the creation of the entire variety of modern physiologically active compounds is played by the synthesis of complexly constructed poly–substituted molecules – analogues of natural substances. Effective design methods involve a significant increase in molecular complexity with a minimum number of stages. However, such an approach often involves complex processes involving multifunctional reagents, which, ultimately, can lead to difficult-to-separate mixtures of the target compound and a number of by-products, both undesirable and promising. This problem remains very significant in the design of various polyazaheterosystems, including those with a pyrazolopyridine skeleton, which is one of the most common fragments in the structures of natural and synthetic biologically active compounds. Therefore, an urgent task is to develop effective methods for the separation of such mixtures and purification of target compounds. Currently, column chromatography is used to solve it, which is one of the most important methods for separating liquid or solid mixtures of organic substances on a preparative scale. In this paper, the reactions of itacone anhydride with substituted 5-amino-1-phenylpyrazoles are investigated, a chromatographic method for separating alternative interaction products and their identification is proposed.
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