Determination of Quetiapine and it’s Metabolites and derivatives in biological samples by Gas-Liquid Chromatography – Mass Spectrometry and High Performance Liquid Chromatography
Keywords:
quetiapine, metabolites, gas-liquid chromatography, mass-spectrometric detection, high-performance liquid chromatography.
Abstract
Advantages and restrictions of GLC-MS and HPLC-DAD methods are considered at
determination of metabolites and derivatives of quetiapine in biological liquids. The estimation of
thermolysis degree of dibenzotiazepine derivatives in GLC conditions is presented. GLC-MS properties
of the identified quetiapine metabolites and derivatives on two phases of different polarity are determined.
The presented variants of quantitative determination quetiapine by GLC-MS (as acetylated form) and
HPLC-DAD methods in biological liquids are based in liquid-liquid and solid-liquid extraction
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References
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2.Skibinski R., Komsta L., Kosztyla I. Comparative validation of quetiapine
Determination in tablets by NP-HPTLC and RP-HPTLC with densitometric and
videodensitometric detection // J. Plan. Chrom. - Modern TLC. 2008. V. 21, P. 289-294
3.Mandriolia R., Fanalib S., Ferrantia A., Raggi M.A. HPLC analysis of the novel
antipsychotic drug quetiapine in human plasma // J. Pharm. Biomed. Anal. 2002. V. 30. P. 969-977
4.Belal F., Elbrashy A., Eid M., Nasr J.J. Stability-Indicating HPLC Method for the
Determination of Quetiapine: Application to Tablets and Human Plasma // J. Liq. Chrom.
& Rel. Techn. // 2008. V. 31. P. 1283 – 1298
5.Davis P.C., Wonga J., Gefvert O. Analysis and pharmacokinetics of quetiapine and two
metabolites in human plasma using reversed-phase HPLC with ultraviolet and
electrochemical detection // J. Pharm. Biomed. Anal. 1999. V. 20. P. 271-282
6.Nirogi R., Bhyrapuneni G., Kandikere V., Mudigonda K., Ajjala D., Mukkanti K.
Sensitive liquid chromatography - tandem mass spectrometry method for the quantification
of Quetiapine in plasma // Biomed. Chrom. 2008. V. 22. P. 1043-1055
7.Kun-yan Li, Ze-neng Cheng, Xin Li, Xue-lian Bai, Bi-kui Zhang, Feng Wang, Huan-de
Li. Simultaneous determination of quetiapine and three metabolites in human plasma by
high-performance liquid chromatography_electrospray ionization mass spectrometry //
Acta Pharmacol. Sin. 2004, V. 25. P. 110-111
8.Bellomarino S.A., Brown A.J., Conlan X.A., Barnett N.W. Preliminary evaluation of
monolithic column high-performance liquid chromatography with tris(2,2′-
bipyridyl)ruthenium(II) chemiluminescence detection for the determination of quetiapine
in human body fluids // Talanta. 2009. V. 77. P. 1873-1876
9.Atanasov V.N., Kanev K.P., Mitewa M.I. Detection and identification of atypical
quetiapine metabolite in urine // Central European Journal of Medicine. 2008. V. 3. P. 327-
331
10. Pullen R.H., Palermo K.M., Curtis M.A. Determination of an antipsychotic agent
(ICI 204,636) and its 7-hydroxy metabolite in human plasma by high-performance liquid
chromatography and gas chromatography—mass spectrometry // J. Chromatogr. B. 1992.
V. 573. P. 49-57
11. Maurer H.H., Pfleger K., Weber A.A. Mass Spectral and GC Data of Drugs, Poisons,
Pesticides, Pollutants and Their Metabolites. Weinheim, Wiley-VCH. 2007. 1432 p.
12. Григорьев А.М., Божко Е.С., Рудакова Л.В. Использование корреляции
индексов удерживания на слабополярных фазах для обзорного анализа сложных
смесей методом хромато-масс-спектрометрии // Журн. аналит. химии. 2009. Т. 64. С. 156-159
13. Clarke's Analysis of Drugs and Poisons, 3 ed. (Ed. by Moffat A.C.). London,
Pharmaceutical Press. 2004. 1248 p.
Published
2019-11-27
How to Cite
Mel`nikA. A., Grigor`evA. M., & Azarova, L. V. (2019). Determination of Quetiapine and it’s Metabolites and derivatives in biological samples by Gas-Liquid Chromatography – Mass Spectrometry and High Performance Liquid Chromatography. Sorbtsionnye I Khromatograficheskie Protsessy, 10(1). Retrieved from https://journals.vsu.ru/sorpchrom/article/view/2018
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