Алгоритм исследования прооксидантной системы организма с целью выбора патогенетической фармакотерапии

Larisa S. Bakulina; Nikolay N. Pluzhnikov; Andrey V. Isaev

doi:10.17308/sorpchrom.2018.18/605

Larisa S. Bakulina M.D., DSci., Full Profes-sor, Dept.of Otorhinolaryngology, Voronezh State Medical University. N.N. Burdenko of the Minis-try of Health of Russia, Voronezh
Nikolay N. Pluzhnikov M.D., DSci., Full Pro-fessor, Research Center of Medico-Biological De-fense, St. Petersburg
Andrey V. Isaev M.D., Assistant Professor, Dept. of Otorhinolaryngology, Voronezh State Medical University. N.N. Burdenko of the Minis-try of Health of Russia; Associate Professor of Clinical Pharmacology Department at Voronezh State University, Voronezh

DOI: https://doi.org/10.17308/sorpchrom.2018.18/605

Keywords: free radicals, prooxidants, antioxidant system, hydroperoxides, free radical oxidation, spectrophotometric methods, chromatographic methods.

Abstract

Regulatory function of free radical processes in cell vital activity supply/provision and their pres-ence as interim step in a number of vital enzymatic reactions determine the topicality of studies devoted to the assessment of free radicals production and inactivation. The study of prooxidant and antioxidant systems and the free radical oxidation intensity makes it possible to solve a lot of problems such as dynamics detec-tion of pathological process activity, the prognosis of one or another pathological condition, the choice of possible ways of prooxidant and antioxidant balance pharmacological correction in inflammatory diseases as well.

Initiation and maintenance of oxidative stress as well as structure impairment and cell death are sometimes considered associated with cell membrane impairment and their lipids peroxidation. The devel-opment of prooxidant system activity rates study algorithm through up-to-date spectrophotometric and chro-matographic methods makes it possible to define and assess step-by-step the rates obtained.

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Prooxidant body system study algorithm with the view of pathogenetic pharmacotherapy option

Abstract

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