Detection of the psychoactive component of smoking mixtures CP47,497 (C8) in urine by gas chromatography – mass spectrometry
Keywords:
CP47,497 (С8), smoking mixtures, urine, GC-MS
Abstract
Prohibition of some synthetic cannabimimetics that have been included in smoking mixtures
(“spices”) occurred in the Russian Federation on January 22, 2010. In this work the method of detection
of the cannabimimetic CP47,497 (С8) in urine of smokers is presented. Sample preparation included
acidic hydrolyses, liquid or solid-liquid extraction steps with the subsequent detection of CP47,497 (С8)
by gas chromatography – mass spectrometry. The retention indices and mass spectra of the acetyl,
trimethylsilyl and trifluoroacetyl derivatives of CP47,497 (С8) are listed. The presented method could be
used for the establishment of CP47,497 (С8) consumption in efforts to forensic chemical and chemical
toxicological analysis
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References
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Drugs (ACMD), London. Website: http://www.homeoffice.
gov.uk/publications/drugs/acmd1/acmd-report-agonists?view=Binary, 2009 (accessed
10.07.2010).
2.European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Thematic
paper–Understanding the ‘Spice’ phenomenon, Luxembourg, 2009, pp. 37.
3.Weissman G.M., Milne L.S., Melvin Jr. Cannabimimetic activity from CP-47,497, a
derivative of 3-phenylcyclohexanol // J. Pharmacol. Exp. Ther. 1982. V. 223. P. 516-523.
4.Auwärter V., Dresen S., Weinmann W., Müller M., Pütz M., Ferreirós N. ‘Spice’ and
other herbal blends: harmless incense or cannabinoid designer drugs? // J. Mass. Spectrom.
2009. V. 44. P. 832–837.
5.Compton D.R., Rice K.C, De Costa B.R, Razdan R.K, Melvin L.S, Johnson M.R,
Martin B.R. Cannabinoid structure-activity relationships: Correlation of receptor binding
and in vivo activities. // J. Pharmacol. Exp. Ther. 1993. V. 265. P. 218-226.
6.Dresen S., Ferreirós N., Pütz M., Westphal F., Zimmermann R., Auwärter V.
Monitoring of herbal mixtures potentially containing synthetic cannabinoids as
psychoactive compounds // J. Mass Spectrom. 2010. V. 45. P. 1186-1194.
7.Uchiyama N., Kikura-Hanajiri R., Ogata J., Goda Y. Chemical analysis of synthetic
cannabinoids as designer drugs in herbal products // Forensic Sci. Int. 2010. V. 198. P. 31-38.
8.Uchiyama N., Kikura-Hanajiri R., Kawahara N., Haishima Y., Goda Y. Identification
of a cannabinoid analog as a new type of designer drug in a herbal product // Chem.
Pharm. Bull. (Tokyo) 2009. V. 57. P. 439-441.
9.Lindigkeit R., Boehme A., Eiserloh I., Luebbecke M., Wiggermann M., Ernst L.,
Beuerle T. Spice: a never ending story? // Forensic Sci. Int. 2009. V. 191. P. 58-63.
Published
2019-11-22
How to Cite
Grigoryev, A. M., Melnik, A. A., Bozhko, E. S., & Savchuk, S. A. (2019). Detection of the psychoactive component of smoking mixtures CP47,497 (C8) in urine by gas chromatography – mass spectrometry. Sorbtsionnye I Khromatograficheskie Protsessy, 12(1). Retrieved from https://journals.vsu.ru/sorpchrom/article/view/1740
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