Analysis of pentoxifylline using matrix-assisted laser/desorption/ionsation, mass spectrometry
Keywords:
matrix-assisted laser/desorption/ionsation, mass spectrometry, pentoxifylline, analysis of pharmaceuticals.
Abstract
The possibility of pentoxifylline analysis using matrix-assisted laser/desorption/ionsation mass
spectrometry (MALDI MS) was investigated. Influence of matrix nature, sample preparation method and
laser settings on mass spectrocoric characteristics were studied. It was shown that MALDI MS allows to
analyze pentoxifylline at 8*10-15 level. Fragmentation pathways of protonated molecular ions were
studied using MALDI mass-spectrometry. The results were compared with respective literature data
received with electrospray ionisation
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References
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Spectrom. 1992. V. 27. P. 53.
2.Danis P.O., Karr D.E., Mayer F., Holle A., Watson C.H. The analysis of water-soluble
polymers by matrix-assisted laser desorption time-of-flight mass spectrometry // J. Org.
Mass Spectrom. 1992. V. 27. P. 843.
3.Hillenkamp F., Peter-Catalinit J. MALDI MS. WILEY-VCH. 2007. с. 363.
4.Cohen L. H., Gusev A. I. Small molecule analysis by MALDI mass spectrometry //
Anal Bioanal Chem. 2002. V. 373. P.571–586.
5. Zabet-Moghaddam M., Heinzle E., Tholey A. Qualitative and quantitative analysis of
low molecular weight compounds by ultraviolet matrix-assisted laser desorption/ionization
mass spectrometry using ionic liquid matrices // Rapid Commun. Mass Spectrom. 2004. V. 18. P. 141.
6.Ayorinde F. O., Garvin K., Saeed K. Determination of the fatty acid composition of
saponified vegetable oils using matrix-assisted laser desorption/ionization time-of-flight
mass spectrometry // Rapid Commun. Mass Spectrom. 2000. V. 14. P. 608.
7.Ling Y-C., Lin L., Chen Y-T. Quantitative Analysis of Antibiotics by Matrixassisted
Laser Desorption/Ionization Time-of-flight Mass Spectrometry // Rapid Commun. Mass
Spectrom. 1998. V. 12. 317.
8. LeRiche T., Osterodt J., Volmer D. A. An experimental comparison of electrospray
ion-trap and matrix-assisted laser desorption/ionization post-source decay mass spectra for
the characterization of small drug molecules // Rapid Commun. Mass Spectrom. 2001. V.
15. P. 608.
9. Sleno L., Volmer D. A. Some fundamental and technical aspects of the quantitative
analysis of pharmaceutical drugs by matrix-assisted laser desorption/ionization mass
spectrometry // Rapid Commun. Mass Spectrom. 2005. V. 19. P. 1928.
10. Crecelius A., Clench M. R., Richards D. S., Parr V. Quantitative determination of
Piroxicam by TLC–MALDI TOF MS // J. Pharm. Biomed. Anal. 2004. V. 35. P. 31.
11. Earnshaw C.J., Carolan V.A., Richards D.S., Clench M.R. Direct analysis of
pharmaceutical tablet formulations using matrix-assisted laser desorption/ionization mass
spectrometry imaging // Rapid Commun. Mass Spectrom. 2010. V. 24. P. 1665.
12. Su A.K., Liu J.T., Lin C.H. Rapid drug-screening of clandestine tablets by MALDITOF
mass spectrometry // Talanta. 2005. V. 67. P. 718.
13. Morrow A. P., Kassim Folahan O. O., Ayorinde O. Detection of cationic surfactants
in oral rinses and a disinfectant formulation using by matrix-assisted laser
desorption/ionization time-of-flight mass spectrometry // Rapid Commun. Mass Spectrom.
2001. V.15. P. 767.
14. Chen Y-C., Shiea J., Sunner J. Rapid determination of trace nitrophenolic organics
in water by combining solid-phase extraction with surface-assisted laser desorption/
ionization time-of-flight mass spectrometry // Rapid Commun. Mass Spectrom. 2000. V. 14. P. 86.
15. Ramakrishna N.V.S., Vishwottan K.N., Manoj S., Santosh M., Anjaneyulu Y. Rapid
liquid chromatographic-tandem mass spectrometric method for the quantification of
pentoxifylline in human plasma // Chromatographia. 2006. V. 63. P. 135.
Published
2019-11-26
How to Cite
Chamyan, K. R., Paramonov, S. A., Revelsky, I. A., & Buryak, A. K. (2019). Analysis of pentoxifylline using matrix-assisted laser/desorption/ionsation, mass spectrometry. Sorbtsionnye I Khromatograficheskie Protsessy, 11(5). Retrieved from https://journals.vsu.ru/sorpchrom/article/view/1972
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