Sorption of some medicinal substances by the Belozersk glauconite

  • Р. К. Чернова Chernova Rimma K. - doctor of chemical sciences, professor of the department of analytical chemistry and chemical ecology of chemical faculty, Saratov national research state university of N. G. Chernyshevsky, Saratov, E-mail: chernov-ia@yandex.ru
  • С. Б. Вениг Venig Sergey B. - doctor of physical mathematical sciences, professor, department of materials science, technology and quality management, Saratov national research state university of N. G. Chernyshevsky, Saratov, E-mail: sergey.venig@mail.ru
  • В. Г. Сержантов Serzhantov Victor G. - candidate of physical mathematical sciences, head of the corporate departament of sorbtionmaterials, Saratov national research state university of N. G. Chernyshevsky, Saratov, E-mail: serzhantov55@mail.ru
  • В. П. Сплюхин Splyukhin Vladimir P. - assistant of the corporate departament of sorbtionmaterials, Saratov national research state university of N. G. Chernyshevsky, Saratov, E-mail: spluhinvp@mail.ru
  • Е. И. Селифонова Selifonova Ekaterina I. - Candidate of Chemical Sciences, Senior research associate, Saratov national research state university of N. G. Chernyshevsky, Saratov, E-mail: selif-ei@yandex.ru
  • Г. Н. Наумова Naumova Galina N. - student of the department of analytical chemistry and chemical ecology, Saratov national research state university of N. G. Chernyshevsky, Saratov, E-mail: naumova.galinka.93@mail.ru
DOI: https://doi.org/10.17308/sorpchrom.2017.17/431
Keywords: glauconite, sorption, medicinal substances, sorption kinetics

Abstract

region have been investigated. Enriched glaukonitе (85%) has been received from glaukonits sand by method of dry magnetic separation. Researches on definition of such adsorptive characteristics as are conducted: measurement of specific surface area, the general porosity, distribution of a time on radiuses. The layered, nanostructured, scaly morphology of a surface of the enriched glaukonite is defined. The big sorption activity of this aluminosilicate is explained by such structure. The sorption ability of the enriched glaukonite is investigated by a spectophotometery methods in relation to some pharmaceutical medicines: to a tetracycline, doxycycline, drotaverin, ambroxol, anaprilin. For the specified substances kinetic curve sorptions are received and sorption capacities are calculated. Analyzing the received dependences, it is possible to judge time of approach of sorption balance in system glaukonite - pharmaceutical substances. Process of sorption of the substances stated above glaukonite proceeds quickly enough, so, within the first 5 seconds of sorption the most part of the dissolved sorbate passes into a sorbent phase (R=64.4 – 69, %), and within 1 minute of sorption extent of extraction reaches 83.3%. Further in system balance is established and there is a saturation of a sorbent. It is established that on sorption kinetics speed medicinal substances are rowed: drotaverin - doxycycline - tetracycline - anaprilin – ambroxol. Drotaverin is occluded much quicker than other substances. However the speed of sorption of all studied substances rather high that demonstrates course of physical adsorption. All studied substances, were occluded in the subacidic environment in the form of hydrochlorides which have in the molecule the protonated atom of nitrogen which is capable to be coordinated with oxygen electrons the silanolnykh and the siloksanovykh of groups of the glaukonit with formation of hydrogen communication. The positive charge of molecules of medicinal substances promotes also their rapprochement with a negatively charged surface of the glaukonite due to electrostatic interaction. Geometrical modeling of molecules of drugs is carried out. The possible mechanism of sorption taking into account character of groups on a surface of silica sorbents, a charge of a surface of the glaukonite, geometry and a hydrophobic factor of molecules of sorbates is discussed.

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Published
2018-02-22
How to Cite
Чернова, Р. К., Вениг, С. Б., Сержантов, В. Г., Сплюхин, В. П., Селифонова, Е. И., & Наумова, Г. Н. (2018). Sorption of some medicinal substances by the Belozersk glauconite. Sorbtsionnye I Khromatograficheskie Protsessy, 17(5), 716-724. https://doi.org/10.17308/sorpchrom.2017.17/431
Issue
Vol 17 No 5 (2017): Sorption and chromatographic processes
Section
Статьи