Study of the influence of the nature and concentration of the solubilizer on the process of formation of solid dispersions of chloronitrophenol
Abstract
Objectives: The aim of the work was to study the influence of surfactants on the release and solubility of chloronitrophenol (CNP) from solid dispersions in water. The object of study was a solid dispersion of chloronitrophenol with PEG 1500.
Experimental: The concentration of the pharmaceutical substance in solutions was determined spectrophotometrically at a wavelength of 410 nm. The study of the solubility and dissolution rate of pharmaceutical substances (PS) in the form of powder and in the composition of solid dispersed systems (SDS) was carried out according to the method proposed by I. I. Krasnyuk. The study of the optical properties of solutions of the initial compounds and solid dispersions was carried out using the method described in the study of V. V. Grikh. IR spectroscopy, differential scanning calorimetry, and electron microscopy were used for investigation of SDS.
Conclusions: The influence of solubilizers on the process of formation of solid dispersions of chloronitrophenol was studied. It has been shown that the presence of solubilizers allows the use of lower concentrations for the carrier when obtaining solid dispersed systems of chloronitrophenol. The conducted complex of physicochemical methods of analysis allows us to more accurately explain the phenomenon of increasing the solubility and dissolution rate of PS from solid dispersions in the presence of a solubilizer. Based on the conducted studies, it can be concluded that the production of solid dispersions based on a carrier polymer in the presence of a solubilizer allows to reduce or completely eliminate the crystallinity of the pharmaceutical substance, converting it into an amorphous state. The presence of the phenomenon of light scattering and the opalescent Faraday-Tyndall cone in solutions containing solid dispersions of CNP confirmed the assumption about a colloidal-dispersed state of the pharmaceutical substance in water when dissolving CNP from solid dispersions.
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