Use of Solid Dispersion Systems in Pharmacy

  • Sof ’ya Yu. Silaeva Voronezh State University https://orcid.org/0000-0002-3007-6271
  • Alena S. Belenova Voronezh State University https://orcid.org/0000-0002-9036-7302
  • Aleksey I. Slivkin Voronezh State University
  • Elena E. Chupandina Voronezh State University
  • Savva R. Naryshkin I. M. Sechenov First Moscow State Medical University (Sechenov University), 8, ul. Trubetskaya, building 2, Mosсow 119991, Russian Federation
  • Ivan I. Krasnyuk (Jr.) I. M. Sechenov First Moscow State Medical University (Sechenov University), 8, ul. Trubetskaya, building 2, Mosсow 119991, Russian Federation https://orcid.org/0000-0002-7242-2988
  • Ivan I. Krasnyuk I. M. Sechenov First Moscow State Medical University (Sechenov University), 8, ul. Trubetskaya, building 2, Mosсow 119991, Russian Federation
Keywords: solid dispersion systems, carriers, medicinal drugs.

Abstract

An overview of the use of solid dispersion systems in pharmacy is presented. The main techniques of obtaining solid dispersions were considered. The simplest one is the solvent removal technique: the medicinal drug and the carrier are dissolved in the solvent that is then evaporated. The fusion method involves heating the mixture of the medicinal drug with the carrier above the fusion temperature with further hardening under quick cooling. The co-milling method is based on the co-use of compression, fracture, and friction energy for the transition of the solid-state drug and carrier into the
amorphous state. The kneading method is a variation of the co-milling method. In this case, the solvent performs several functions at the same time: it dissolves one of the components and enters the micro-fi ssures of crystals of another component, producing a wedge effect and contributing to the milling and interpenetration of one substance into the pores of another. The method of using the agents stabilising the amorphous state of the medicinal drug involves mixing the following components: a sparingly soluble medicinal drug, an agent inducing the transition of the system into the amorphous state, and an agent stabilising its amorphous state. The obtained mixture is subjected to thermal or mechanochemical treatment. Combinations of these methods are also used to obtain solid dispersion systems. Examples of polymers and non-polymer substances used as carriers in solid dispersion systems are given. The works of authors were studied that are dedicated to the creation and study of solid dispersions of various active pharmaceutical ingredients as well as dosage forms produced from these solid dispersions.

 

 

 

 

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Author Biographies

Sof ’ya Yu. Silaeva, Voronezh State University

postgraduate student, Department of Pharmacy Management and Economics and Pharmacognosy, Voronezh State University, Voronezh, Russian Federation; e-mail: sophiasilaeva@yandex.ru.

Alena S. Belenova, Voronezh State University

PhD in biology, Assistant of the Department of Pharmaceutical Chemistry and Pharmaceutical Technology, Voronezh State University, Voronezh, Russian Federation; e-mail: alenca198322@mail.ru.

Aleksey I. Slivkin, Voronezh State University

DSc in Pharmacy, Professor, Head of the Department of Pharmaceutical Chemistry and
Pharmaceutical Technology, Voronezh State University, Voronezh, Russian Federation; e-mail: slivkin@pharm.vsu.ru.

Elena E. Chupandina, Voronezh State University

DSc in Pharmacy, Professor, Head of the Department of Pharmacy Management
and Economics and Pharmacognosy, Voronezh State University, Voronezh, Russian Federation; e-mail:
chupandina@vsu.ru.

Savva R. Naryshkin, I. M. Sechenov First Moscow State Medical University (Sechenov University), 8, ul. Trubetskaya, building 2, Mosсow 119991, Russian Federation

postgraduate student, Department of Analytical, Physical and Colloid Chemistry, A. P. Nelyubin Institute of Pharmacy, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; e-mail: lonely.sloka@yandex.ru.

Ivan I. Krasnyuk (Jr.), I. M. Sechenov First Moscow State Medical University (Sechenov University), 8, ul. Trubetskaya, building 2, Mosсow 119991, Russian Federation

DSc in Pharmacy, Professor, Head of the Department of Analytical, Physical and Colloid Chemistry, A. P. Nelyubin Institute of Pharmacy, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; e-mail: krasnyuk.79@mail.ru.

Ivan I. Krasnyuk, I. M. Sechenov First Moscow State Medical University (Sechenov University), 8, ul. Trubetskaya, building 2, Mosсow 119991, Russian Federation

DSc in Pharmacy, Professor, Head of the Department of Pharmaceutical Technology, A. P. Nelyubin Institute of Pharmacy, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation; e-mail: krasnyuki@mail.ru.

Published
2020-06-25
How to Cite
Silaeva, S. ’ya Y., Belenova, A. S., Slivkin, A. I., Chupandina, E. E., Naryshkin, S. R., Krasnyuk (Jr.), I. I., & Krasnyuk, I. I. (2020). Use of Solid Dispersion Systems in Pharmacy. Kondensirovannye Sredy I Mezhfaznye Granitsy = Condensed Matter and Interphases, 22(2), 173-181. https://doi.org/10.17308/kcmf.2020.22/2820
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