Synthesis of carboxymethyl cellulose sodium salt and N-vinylimidazole graft copolymers and their aqueous solutions property researching

  • Vyacheslav A. Kuznetsov Voronezh State University 1, Universitetskaya pl., 394018 Voronezh, Russian Federation
  • Maria S. Lavlinskaya Voronezh State University 1, Universitetskaya pl., 394018 Voronezh, Russian Federation
  • Andrey V. Sorokin Voronezh State University 1, Universitetskaya pl., 394018 Voronezh, Russian Federation
Keywords: graft copolymers,, carboxymethyl cellulose,, N-vinylimidazole,, polymer solutions

Abstract

Purpose. The aim of this work is synthesis of carboxymethyl cellulose sodium salt (Na-CMC) and N-vinylimidazole (VI) graft copolymers and investigation of the properties of their water solutions.

Methods and methodology. The Na-CMC-g-VI co-polymers with different content of VI were obtained by free radical polymerization with ox-red initiator system (Table 1). Selective precipitation and dialysis were used to remove unreacted Na-CMC, VI and other excess components.

Results. The structure, compound and grafting effi ciency (GE) of the synthesized co-polymers were determined by Fourier transmission infrared spectroscopy (Table 1). Polymerization kinetics for all samples is researched by co-polymer composition determination with UV spectroscopy use, and was found that it was ending during 180 minutes (Fig. 1) Molecular weights of grafted poly-N-vinylimidazole were calculated from gel permeation chromatography static light scattering data. It was found that GE value is maximal for co-polymer containing 43 % w of VI (Table 2). Dynamic light scattering (DLS) and transmission electron microscopy researching showed that particles of all synthesized co-polymers in water possess non-spherical form (Fig. 2), and their surfaces have negative values of zeta-potential (Table 3). The hydrodynamic radii of the polymer particles are in the range of 120-152 nm, and slightly increase with VI content growth. It was found by DLS that polymer particles of all copolymers are stable in 0.15 M NaCl aqueous solution and in the wide pH range which allows to apply them as vectors for targeted drug delivery (Fig. 3, 4).

Conclusion. To sum up, Na-CMC-g-VI co-polymers were prepared by free radical copolymerization with ox-red initiator system. Aqueous solutions of the synthesized co-polymers were characterized by dynamic light scattering, transmission electron microscopy and zeta-potential measurement.

 

 

REFERENCES

  1. Madruga E. From classical to living/controlled statistical free-radical copolymerization // Prog. Polym. Sci., 2002, v. 27, pp. 1879–1924. https://doi.org/10.1016/S0079-6700(02)00023-0
  2. Barouti G., Jaffredo C. G., Guillaume S. M. Advances in drug delivery systems based on synthetic poly(hydroxybutyrate) (co)polymers // Polym. Sci., 2017, v. 73, pp. 1–31. https://doi.org/10.1016/j.progpolymsci. 2017.05.002
  3. Kabanov A. V., Vinogradov S. V. Nanogels as pharmaceutical carriers: fi nite networks of infi nite capabilities // Chem. Int. Ed., 2009, v. 48, pp. 5418–5429. https://doi.org/10.1002/anie.200900441
  4. Oh J. K., Drumright R., Siegwart D., Matyjaszewski K. The development of microgels/nanogels for drug delivery applications // Polym. Sci., 2008, v. 33, pp. 448–477. https://doi.org/10.1016/j.progpolymsci.2008.01.002
  5. Kuznetsov V. A., Lavlinskaya M. S., Ostankova I. V. Synthesis of N-vinylformamide and 1-vinyl-(1-methacryloyl)-3,5-dimethylpyrazole copolymers and their extraction ability in relation to histidine in watersalt media // Bull., 2018, v. 75, pp. 1237–1251. https://doi.org/10.1007/s00289-017-2091-2
  6. Bhattacharya A., Misra B. Grafting: a versatile means to modify polymersTechniques, factors and applications // Polym. Sci., 2004, v. 29, pp. 767–814.  https://doi.org/10.1016/j. progpolymsci.2004.05.002
  7. Rasoulzadeh M., Namaz H. Carboxymethyl cellulose/graphene oxide bio-nanocomposite hydrogel beads as anticancer drug carrier agent // Polym., 2017, v. 168, pp. 320–326. https://doi.org/10.1016/j.carbpol. 2017.03.014
  8. Worzakowska M. Chemical modifi cation of potato starch by graft copolymerization with citronellyl methacrylate // Polym. Environ., 2018, v. 26, pp. 1613–1624. https://doi.org/10.1007/s10924-017-1062-x
  9. Kuznetsov V. A., Kushchev P. O., Blagodat skikh I. V. Aqueous dispersions of cross-linked poly-N-vinylcaprolactam stabilized with hydrophobically modified polyacrylamide: synthesis, colloidal stability, and thermosensitive properties // Polym. Sci., 2016, v. 294, pp. 889–899. https://doi.org/10.1007/s00396-016-3843-5
  10. Gen, Uzun C., Güven O. Quaternized poly(1-vinylimidazole) hydrogel for anion adsorption // Polym. Bull., 2016, v. 73, pp. 179–190. https://doi.org/10.1007/s00289-015-1479-0
  11. Jakubiak-Marcinkowska A, Legan M, Jezierska J. Molecularly imprinted polymeric Cu(II) catalysts with modified active centres mimicking oxidation enzymes // Polym. Res., 2013, v. 20(12), pp. 317–328. https://doi.org/10.1007/ s10965-013-0317-z

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Author Biographies

Vyacheslav A. Kuznetsov, Voronezh State University 1, Universitetskaya pl., 394018 Voronezh, Russian Federation

Kuznetsov Vyacheslav A. – Dr. Sci. (Chem.), Professor, Polymer Science and Colloid Chemistry Department, Voronezh State University, Voronezh, Russian Federation; e-mail: dr.v.kuznetsov@gmail.com. ORCID: 0000-0002-0072-2025.

Maria S. Lavlinskaya, Voronezh State University 1, Universitetskaya pl., 394018 Voronezh, Russian Federation

Lavlinskaya Maria S. – Cand. Sci. (Chem.), Junior Researcher of Molecular Biotechnology, Voronezh
State University, Voronezh, Russian Federation; e-mail: maria.lavlinskaya@gmail.com. ORCID:
0000-0001-9058-027X.

Andrey V. Sorokin, Voronezh State University 1, Universitetskaya pl., 394018 Voronezh, Russian Federation

Sorokin Andrey V. – 2nd year education Master Student, Polymer Science and Colloid Che mistry
Department, Voronezh State University, Voro nezh, Russian Federation; ORCID: 0000-0001-5268-
9557.

Published
2019-06-14
How to Cite
Kuznetsov, V. A., Lavlinskaya, M. S., & Sorokin, A. V. (2019). Synthesis of carboxymethyl cellulose sodium salt and N-vinylimidazole graft copolymers and their aqueous solutions property researching. Kondensirovannye Sredy I Mezhfaznye Granitsy = Condensed Matter and Interphases, 21(2), 231-239. https://doi.org/10.17308/kcmf.2019.21/761
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Статьи